| Host: | Rabbit |
| Applications: | CM/ELISA/ICC/IF/IHC/IP/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-PDE4B (C-Term) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.68 µg/µl |
| Dilution Range: | WB: 1:500-1:1, 000DB: 1:10, 000ELISA: 1:10, 000IP: 1:350IHC: 1:250ICC: 1:250IF: 1:250CFM: 1:250 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | PDE4B |
| Gene ID: | 5142 |
| Uniprot ID: | PDE4B_HUMAN |
| Immunogen Region: | C-Term |
| Specificity: | Does not cross-react with other PDE family members such as PDE4A, PDE4C, or PDE4D. |
| Immunogen: | Synthetic peptide common to all PDE4B subtypes taken near C-terminal |
| Tissue Specificity | Expressed in brain, heart, lung and skeletal muscle. Expressed in white blood cells. Isoform PDE4B5: Brain-specific isoform. |
| Function | Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. |
| Protein Name | 3' -5'-Cyclic-Amp Phosphodiesterase 4bDpde4Pde32Camp-Specific Phosphodiesterase 4b |
| Database Links | Reactome: R-HSA-180024 Q07343-3 |
| Cellular Localisation | Isoform Pde4b5: CytoplasmCell Membrane |
| Alternative Antibody Names | Anti-3' -5'-Cyclic-Amp Phosphodiesterase 4b antibodyAnti-Dpde4 antibodyAnti-Pde32 antibodyAnti-Camp-Specific Phosphodiesterase 4b antibodyAnti-PDE4B antibodyAnti-DPDE4 antibody |
Information sourced from Uniprot.org
