Anti-PDE3B antibody (260-310) (STJ506001)

SKU:
STJ506001-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Chicken/Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PDE3B (260-310) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 1.0-1.25 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE3B
Gene ID: 5140
Uniprot ID: PDE3B_HUMAN
Immunogen Region: 260-310
Immunogen: Synthetic peptide taken within amino acid region 260-310 on human PDE3B protein. Selective only for PDE3B variant.
Tissue Specificity Abundant in adipose tissues.
Post Translational Modifications Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B.
Function Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes.
Protein Name Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b
Cgipde1
Cgip1
Cyclic Gmp-Inhibited Phosphodiesterase B
Cgi-Pde B
Database Links Reactome: R-HSA-165160
Reactome: R-HSA-418555
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b antibody
Anti-Cgipde1 antibody
Anti-Cgip1 antibody
Anti-Cyclic Gmp-Inhibited Phosphodiesterase B antibody
Anti-Cgi-Pde B antibody
Anti-PDE3B antibody

Information sourced from Uniprot.org

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