• Immunohistochemistry of baboon lung with Anti-PDE2A primary antibody (STJ502250) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-PDE2A antibody (1-50) (STJ502250)

SKU:
STJ502250-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PDE2A (1-50) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE2A
Gene ID: 5138
Uniprot ID: PDE2A_HUMAN
Immunogen Region: 1-50
Specificity: This antibody will detect PDE2A1 only.
Immunogen: Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A1 protein.
Tissue Specificity Widely expressed. Expressed in brain, with high expression observed in the corpus striatum. Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas.
Function cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
Protein Name Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase
Cyclic Gmp-Stimulated Phosphodiesterase
Cgs-Pde
Cgspde
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-418555
Cellular Localisation Isoform Pde2a3: Cell Membrane
Lipid-Anchor
Isoform Pde2a2: Mitochondrion Matrix
Mitochondrion Inner Membrane
Mitochondrion Outer Membrane
Isoform Pde2a1: Cytoplasm
Isoform 5: Mitochondrion
Alternative Antibody Names Anti-Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase antibody
Anti-Cyclic Gmp-Stimulated Phosphodiesterase antibody
Anti-Cgs-Pde antibody
Anti-Cgspde antibody
Anti-PDE2A antibody

Information sourced from Uniprot.org

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