| Host: |
Rabbit |
| Applications: |
ELISA/IHC/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PDE2A (1-50) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Biotin |
| Isotype: |
IgG |
| Purification: |
Affinity Purified |
| Concentration: |
0.5 µg/µl |
| Dilution Range: |
WB: 1:500ELISA: 1:10, 000IP: 1:200IHC: 1:100 |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PDE2A |
| Gene ID: |
5138 |
| Uniprot ID: |
PDE2A_HUMAN |
| Immunogen Region: |
1-50 |
| Specificity: |
This antibody will detect PDE2A3 only. |
| Immunogen: |
Synthetic peptide corresponding to region within amino acids 1-50 on N-terminus of human PDE2A3 protein. |
| Tissue Specificity | Widely expressed. Expressed in brain, with high expression observed in the corpus striatum. Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas. |
| Function | cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L. |
| Protein Name | Cgmp-Dependent 3' -5'-Cyclic PhosphodiesteraseCyclic Gmp-Stimulated PhosphodiesteraseCgs-PdeCgspde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform Pde2a3: Cell MembraneLipid-AnchorIsoform Pde2a2: Mitochondrion MatrixMitochondrion Inner MembraneMitochondrion Outer MembraneIsoform Pde2a1: CytoplasmIsoform 5: Mitochondrion |
| Alternative Antibody Names | Anti-Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase antibodyAnti-Cyclic Gmp-Stimulated Phosphodiesterase antibodyAnti-Cgs-Pde antibodyAnti-Cgspde antibodyAnti-PDE2A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
