Host: | Rabbit |
Applications: | ELISA/IHC/IP/WB |
Reactivity: | Human/Monkey/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-PDE12 (370-420) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Biotin |
Isotype: | IgG |
Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
Purification: | Affinity Purified |
Concentration: | 0.5 µg/µl |
Dilution Range: | WB: 1:500ELISA: 1:10, 000IP: 1:200IHC: 1:100 |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | PDE12 |
Gene ID: | 201626 |
Uniprot ID: | PDE12_HUMAN |
Immunogen Region: | 370-420 |
Immunogen: | Synthetic peptide taken within amino acid region 370-420 on human PDE12 protein. |
Tissue Specificity | Ubiquitous. |
Function | Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells. |
Protein Name | 2' -5'-Phosphodiesterase 122'-Pde2-PdeMitochondrial Deadenylase |
Database Links | Reactome: R-HSA-8983711 |
Cellular Localisation | Mitochondrion Matrix |
Alternative Antibody Names | Anti-2' -5'-Phosphodiesterase 12 antibodyAnti-2'-Pde antibodyAnti-2-Pde antibodyAnti-Mitochondrial Deadenylase antibodyAnti-PDE12 antibody |
Information sourced from Uniprot.org