Anti-PDCL3 antibody (1-239aa) [AT8F9] (STJA0041712)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human PDCL3 (1-239aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-PDCL3 (1-239aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT8F9 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PDCL3 |
| Gene ID | 79031 |
| Uniprot ID | PDCL3_HUMAN |
| Accession Number | NP_076970 |
| Immunogen | Recombinant human PDCL3 (1-239aa) purified from E. coli |
| Immunogen Region | 1-239aa |
Additional Info
| Tissue Specificity | Expressed in endothelial cells (at protein level). Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine and colon. |
| Post Translational Modifications | N-terminal methionine acetylation destabilizes the protein. |
| Function | Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation. Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding. Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes. Modulates the activation of caspases during apoptosis. |
| Protein Name | Phosducin-Like Protein 3HtphlpPhpl3Viral Iap-Associated Factor 1Viaf-1 |
| Database Links | |
| Cellular Localisation | CytoplasmPerinuclear RegionEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Phosducin-Like Protein 3 antibodyAnti-Htphlp antibodyAnti-Phpl3 antibodyAnti-Viral Iap-Associated Factor 1 antibodyAnti-Viaf-1 antibodyAnti-PDCL3 antibodyAnti-PhLP2A antibodyAnti-VIAF1 antibody |
Information sourced from Uniprot.org