| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PCSK1 |
| Gene ID: | 5122 |
| Uniprot ID: | NEC1_HUMAN |
| Immunogen Region: | 28-170 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 28-170 of human PCSK1 (NP_000430.3). |
| Immunogen Sequence: | KRQFVNEWAAEIPGGPEAAS AIAEELGYDLLGQIGSLENH YLFKHKNHPRRSRRSAFHIT KRLSDDDRVIWAEQQYEKER SKRSALRDSALNLFNDPMWN QQWYLQDTRMTAALPKLDLH VIPVWQKGITGKGVVITVLD DGL |
| Post Translational Modifications | O-glycosylated. |
| Function | Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP. |
| Protein Name | Neuroendocrine Convertase 1Nec 1Prohormone Convertase 1Proprotein Convertase 1Pc1 |
| Database Links | Reactome: R-HSA-209952Reactome: R-HSA-264876Reactome: R-HSA-381771Reactome: R-HSA-400511Reactome: R-HSA-422085 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleLocalized In The Secretion Granules |
| Alternative Antibody Names | Anti-Neuroendocrine Convertase 1 antibodyAnti-Nec 1 antibodyAnti-Prohormone Convertase 1 antibodyAnti-Proprotein Convertase 1 antibodyAnti-Pc1 antibodyAnti-PCSK1 antibodyAnti-NEC1 antibody |
Information sourced from Uniprot.org