| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:100-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PCDH15 |
| Gene ID: | 65217 |
| Uniprot ID: | PCD15_HUMAN |
| Immunogen Region: | 160-400 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-400 of human PCDH15 (NP_001136235.1). |
| Immunogen Sequence: | TVNELTPVGTTIFTGFSGDN GATDIDDGPNGQIEYVIQYN PDDPTSNDTFEIPLMLTGNI VLRKRLNYEDKTRYFVIIQA NDRAQNLNERRTTTTTLTVD VLDGDDLGPMFLPCVLVPNT RDCRPLTYQAAIPELRTPEE LNPIIVTPPIQAIDQDRNIQ PPSDRPGILYSILVGTPEDY PRFFHMHPRTAELSLLEPVN RDFHQKFDLVIKAEQDNGHP LPAFAGLHIEILDENNQSP |
| Tissue Specificity | Expressed in brain, lung, kidney, spleen and testis. Found also in the inner and outer synaptic layers, and the nerve fiber layer in adult and fetal retinas. Found in the supporting cells, outer sulcus cells and spiral ganglion of fetal cochlea. Expressed in cytotoxic tumor-derived T- and NK-cell lines as well as biopsies of nasal NK/T-cell lymphomas. Not detected in normal or in vitro activated peripheral blood cells, CD4 or CD8 lymphocytes or NK cells. Isoform 3 is expressed in brain, heart, cerebellum and kidney. CD1 isoforms, such as isoform 1, have a limited pattern of expression and is detected in testis, retina and cochlea. CD2 isoforms, such as isoforms 4 and 5, are expressed in heart, kidney, thymus, spleen, testis, retina and cochlea. CD3 isoforms, such as isoform 6, are widely expressed. |
| Function | Calcium-dependent cell-adhesion protein. Essential for maintenance of normal retinal and cochlear function. |
| Protein Name | Protocadherin-15 |
| Database Links | Reactome: R-HSA-9662360 Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Efficient Localization To The Plasma Membrane Requires The Presence Of Lhfpl5 Isoform 3: Secreted |
| Alternative Antibody Names | Anti-Protocadherin-15 antibody Anti-PCDH15 antibody Anti-USH1F antibody |
Information sourced from Uniprot.org