| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PolyrC-binding protein 2 (30-110 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PCBP2 |
| Gene ID: |
5094 |
| Uniprot ID: |
PCBP2_HUMAN |
| Immunogen Region: |
30-110 aa |
| Specificity: |
PCBP2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 30-110 |
| Post Translational Modifications | Phosphorylated. The non-phosphorylated form(s) exhibited the strongest poly(rC)-binding activity. (Microbial infection) Proteolytically cleaved by picornavirus proteinase 3CD. |
| Function | Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Major cellular poly(rC)-binding protein. Binds also poly(rU). Acts as a negative regulator of antiviral signaling. Negatively regulates cellular antiviral responses mediated by MAVS signaling. It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation. Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid-like droplets in which CGAS is activated. Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing. (Microbial infection) In case of infection by poliovirus, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation. Also plays a role in initiation of viral RNA replication in concert with the viral protein 3CD. |
| Protein Name | Poly(Rc-Binding Protein 2Alpha-Cp2Heterogeneous Nuclear Ribonucleoprotein E2Hnrnp E2 |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203Reactome: R-HSA-936440Reactome: R-HSA-9692916 |
| Cellular Localisation | NucleusCytoplasmLoosely Bound In The NucleusMay Shuttle Between The Nucleus And The Cytoplasm |
| Alternative Antibody Names | Anti-Poly(Rc-Binding Protein 2 antibodyAnti-Alpha-Cp2 antibodyAnti-Heterogeneous Nuclear Ribonucleoprotein E2 antibodyAnti-Hnrnp E2 antibodyAnti-PCBP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
