Anti-PAX6 antibody (1-422) (STJ29473)

Name: Anti-PAX6 antibody (1-422) (STJ29473)
SKU: STJ29473
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ29473

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Short Description	Rabbit polyclonal PAX6 (1-422) antibody for use in WB, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IF/ICC/IP/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 IF/ICC:1:50-1:200 IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-600 Mu g extracts of whole cells ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	PAX6
Gene ID	5080
Uniprot ID	PAX6_HUMAN
Immunogen Region	1-422
Immunogen Sequence	MQNSHSGVNQLGGVFVNGRP LPDSTRQKIVELAHSGARPC DISRILQVSNGCVSKILGRY YETGSIRPRAIGGSKPRVAT PEVVSKIAQYKRECPSIFAW EIRDRLLSEGVCTNDNIPSV SSINRVLRNLASEKQQMGAD GMYDKLRMLNGQTGSWGTRP GWYPGTSVPGQPTQDGCQQQ EGGGENTNSISSNGEDSDEA QMRLQLKRKLQRNRTSFTQE QIEALEKEFERTHYPDVFA
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PAX6 (NP_000271.1).

Tissue Specificity	Isoform 1: Expressed in lymphoblasts. Isoform 5a: Weakly expressed in lymphoblasts.
Post Translational Modifications	Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation.
Function	Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression.
Protein Name	Paired Box Protein Pax-6 Aniridia Type Ii Protein Oculorhombin
Database Links	Reactome: R-HSA-210745 Reactome: R-HSA-381771 Reactome: R-HSA-400511 Reactome: R-HSA-5617472 Reactome: R-HSA-9823739
Cellular Localisation	Nucleus Isoform 1: Nucleus Isoform 5a: Nucleus
Alternative Antibody Names	Anti-Paired Box Protein Pax-6 antibody Anti-Aniridia Type Ii Protein antibody Anti-Oculorhombin antibody Anti-PAX6 antibody Anti-AN2 antibody

Information sourced from Uniprot.org