Host: |
Rabbit |
Applications: |
WB/IHC/IP |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit monoclonal antibody anti-PAX5 (200-300) is suitable for use in Western Blot, Immunohistochemistry and Immunoprecipitation research applications. |
Clonality: |
Monoclonal |
Clone ID: |
S9MR |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:100-1:500IHC-P 1:50-1:200IP 1:50-1:200 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
PAX5 |
Gene ID: |
5079 |
Uniprot ID: |
PAX5_HUMAN |
Immunogen Region: |
200-300 |
Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PAX5 (Q02548). |
Immunogen Sequence: |
DEGIQESPVPNGHSLPGRDF LRKQMRGDLFTQQQLEVLDR VFERQHYSDIFTTTEPIKPE QTTEYSAMASLAGGLDDMKA NLASPTPADIGSSVPGPQSY P |
Post Translational Modifications | O-glycosylated. Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation. |
Function | Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire. (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription. Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity. |
Protein Name | Paired Box Protein Pax-5B-Cell-Specific Transcription FactorBsap |
Database Links | Reactome: R-HSA-8939245 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Paired Box Protein Pax-5 antibodyAnti-B-Cell-Specific Transcription Factor antibodyAnti-Bsap antibodyAnti-PAX5 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance