Anti-PAX-5 antibody IHC Human lymph node STJ180298

Anti-Recombinant-PAX-5 antibody (Full length) [ZM26] (STJ180298)

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STJ180298
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Short Description :Mouse monoclonal Recombinant-PAX-5 (Full length) antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC-P
Host:Mouse
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :ZM26
Isotype:IgG1k
Conjugation:Unconjugated
Purification:Affinity purified
Dilution Range:1:100‐200
Formulation:Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Storage Instruction:Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Gene Symbol:PAX5
Gene ID:5079
Uniprot ID:PAX5_HUMAN
Immunogen:Recombinant human full-length PAX-5 protein
Immunogen Region:Full length
Specificity:Positive control: Tonsil
Post Translational Modifications O-glycosylated. Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation.
Function Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire. (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription. Also participates in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity.
Protein Name Paired Box Protein Pax-5
B-Cell-Specific Transcription Factor
Bsap
Database Links Reactome: R-HSA-8939245
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Paired Box Protein Pax-5 antibody
Anti-B-Cell-Specific Transcription Factor antibody
Anti-Bsap antibody
Anti-PAX5 antibody

Information sourced from Uniprot.org

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