Anti-PAX-2 antibody [EP235] (STJ16101670)

Anti-PAX-2 antibody [EP235] (STJ16101670)

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STJ16101670-1
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Short Description :Rabbit monoclonal anti-PAX-2 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Applications:IHC-P
Host:Rabbit
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :EP235
Conjugation:Unconjugated
Dilution Range:IHC-P 1:10-1:50
Formulation:Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide
Storage Instruction:Store at 2-8°C for up to 1-year, upon receipt.
Background PAX2 is a member of the paired box family of transcription factors, which is required for development and proliferation of the kidney, brain, and mllerian organs. PAX2 genes contain a highly conserved DNA sequence within the paired box region, which encodes a DNA-binding domain, enabling PAX proteins to bind the promoters of specific genes to transcriptionally regulate their expression. PAX2 is specifically expressed in the developing central nervous system, eye, ear, and urogenital tract, and is essential for the development of these organs. In normal adult tissues PAX2 was mainly detected in the urogenital system, including kidney, ureteric epithelium, fallopian tube epithelium, ovary and uterus. In tumors, PAX2 has been detected in renal cell carcinomas, Wilms tumors, nephrogenic adenomas and papillary serous carcinoma of the ovary. PAX2 has been used as a marker for the identification of renal cell carcinoma and ovarian carcinoma by immunohistochemistry.

Information sourced from Uniprot.org

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