| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-InaD-like protein is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PATJ |
| Uniprot ID: | INADL_HUMAN |
| Specificity: | This antibody detects endogenous levels of INADL at Human, Mouse |
| Immunogen: | Synthesized peptide derived from human INADL |
| Function | Scaffolding protein that facilitates the localization of proteins to the cell membrane. Required for the correct formation of tight junctions and epithelial apico-basal polarity. Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells. Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries. |
| Protein Name | Inad-Like Protein Inadl Protein Hinadl Channel-Interacting Pdz Domain-Containing Protein Pals1-Associated Tight Junction Protein Protein Associated To Tight Junctions |
| Cellular Localisation | Cell Junction Tight Junction Apical Cell Membrane Peripheral Membrane Protein Cytoplasm Perinuclear Region Localizes To The Apical Region At The Start Of Epithelial Cell Polarization Then Locates To Tight Junctions As Polarization Is Completed Localized In The Paranodal Region Of Myelinating Schwann Cells Localized To The Leading Edge Of The Actin Cortex Of Migrating Epithelia Cells |
| Alternative Antibody Names | Anti-Inad-Like Protein antibody Anti-Inadl Protein antibody Anti-Hinadl antibody Anti-Channel-Interacting Pdz Domain-Containing Protein antibody Anti-Pals1-Associated Tight Junction Protein antibody Anti-Protein Associated To Tight Junctions antibody Anti-PATJ antibody Anti-CIPP antibody Anti-INADL antibody |
Information sourced from Uniprot.org
