| Function | Scaffolding protein that facilitates the localization of proteins to the cell membrane. Required for the correct formation of tight junctions and epithelial apico-basal polarity. Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier. Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells. Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration. May regulate the surface expression and/or function of ASIC3 in sensory neurons. May recruit ARHGEF18 to apical cell-cell boundaries. |
| Protein Name | Inad-Like ProteinInadl ProteinHinadlChannel-Interacting Pdz Domain-Containing ProteinPals1-Associated Tight Junction ProteinProtein Associated To Tight Junctions |
| Database Links | Reactome: R-HSA-420029Reactome: R-HSA-9705677 |
| Cellular Localisation | Cell JunctionTight JunctionApical Cell MembranePeripheral Membrane ProteinCytoplasmPerinuclear RegionLocalizes To The Apical Region At The Start Of Epithelial Cell Polarization Then Locates To Tight Junctions As Polarization Is CompletedLocalizes To The Most Apical Strand Of Tjp1/Zo1 Condensates During Junctional Condensation ElongationLocalized In The Paranodal Region Of Myelinating Schwann CellsLocalized To The Leading Edge Of The Actin Cortex Of Migrating Epithelia Cells |
| Alternative Antibody Names | Anti-Inad-Like Protein antibodyAnti-Inadl Protein antibodyAnti-Hinadl antibodyAnti-Channel-Interacting Pdz Domain-Containing Protein antibodyAnti-Pals1-Associated Tight Junction Protein antibodyAnti-Protein Associated To Tight Junctions antibodyAnti-PATJ antibodyAnti-CIPP antibodyAnti-INADL antibody |
Information sourced from Uniprot.org
