| Post Translational Modifications | Auto-ADP-ribosylated. |
| Function | ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'. Mono-ADP-ribosylates STAT6.enhancing STAT6-dependent transcription. In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation. Mono-ADP-ribosylates PARP9. |
| Protein Name | Protein Mono-Adp-Ribosyltransferase Parp14Adp-Ribosyltransferase Diphtheria Toxin-Like 8Artd8B Aggressive Lymphoma Protein 2Poly Adp-Ribose Polymerase 14Parp-14 |
| Database Links | Reactome: R-HSA-197264Reactome: R-HSA-9683610Reactome: R-HSA-9694631 |
| Cellular Localisation | NucleusCytoplasmIn Steady State Splenocytes The Protein Is Mostly NuclearA Minor Proportion Is Detected In The CytoplasmIn MacrophagesMainly Localizes To The Cytoplasm |
| Alternative Antibody Names | Anti-Protein Mono-Adp-Ribosyltransferase Parp14 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 8 antibodyAnti-Artd8 antibodyAnti-B Aggressive Lymphoma Protein 2 antibodyAnti-Poly Adp-Ribose Polymerase 14 antibodyAnti-Parp-14 antibodyAnti-PARP14 antibodyAnti-BAL2 antibodyAnti-KIAA1268 antibody |
Information sourced from Uniprot.org
