| Short Description : | Rabbit polyclonal anti-Parathyroid hormone 2 receptor (aa: 481-501) for use in WB in Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | Mixed |
| Conjugation: | Unconjugated |
| Purification: | Whole serum |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at-20°C for a higher stability, and at 2-8°C with an appropriate antibacterial |
| Gene Symbol: | Pth2r |
| Gene ID: | 81753 |
| Uniprot ID: | PTH2R_RAT |
| Immunogen: | A synthetic peptide (RQIDSHVTLPGYVWSSSEQDC) of rat Parathyroid hormone receptor protein (aa: 481-501) conjugated to KLH has been used as the immunogen. |
| Immunogen Region: | aa: 481-501 |
| Immunogen Sequence: | Rat |
| Specificity: | Specificity has been shown by Western blot. A band of 63 kDa corresponding to the theoretical molecular weight of Parathyroid hormone receptor is easily detectable by WB. Absorption of the antiserum with the immunising peptide abolished the binding o |
| Tissue Specificity | Abundantly expressed in brain, arterial and cardiac endothelium. Found as well in sperm, in the head of the epididymis. Lower expression is found in vascular smooth muscle, exocrine pancreas, testis and placenta. |
| Function | This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. |
| Protein Name | Parathyroid Hormone 2 ReceptorPth2 Receptor |
| Database Links | Reactome: R-RNO-373080 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Parathyroid Hormone 2 Receptor antibodyAnti-Pth2 Receptor antibodyAnti-Pth2r antibodyAnti-Pthr2 antibody |
Information sourced from Uniprot.org
