| Tissue Specificity | Widely expressed. Expression is elevated in various neurodegenerative diseases such as amyotrophic lateral sclerosis, Alzheimer, Parkinson and Huntington diseases and stroke. Down-regulated in several cancers. |
| Post Translational Modifications | Preferentially phosphorylated at the Thr-163 by PKC in cancer cells. |
| Function | Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1. |
| Protein Name | Prkc Apoptosis Wt1 Regulator ProteinProstate Apoptosis Response 4 ProteinPar-4 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusMainly Cytoplasmic In Absence Of Apoptosis Signal And In Normal CellsNuclear In Most Cancer Cell LinesNuclear Entry Seems To Be Essential But Not Sufficient For ApoptosisNuclear Localization Includes Nucleoplasm And Pml Nuclear Bodies |
| Alternative Antibody Names | Anti-Prkc Apoptosis Wt1 Regulator Protein antibodyAnti-Prostate Apoptosis Response 4 Protein antibodyAnti-Par-4 antibodyAnti-PAWR antibodyAnti-PAR4 antibody |
Information sourced from Uniprot.org
