| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Pappalysin-1 (30-110 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PAPPA |
| Gene ID: | 5069 |
| Uniprot ID: | PAPP1_HUMAN |
| Immunogen Region: | 30-110 aa |
| Specificity: | PAPP1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 30-110 |
| Post Translational Modifications | There appear to be no free sulfhydryl groups. |
| Function | Metalloproteinase which specifically cleaves IGFBP-4 and IGFBP-5, resulting in release of bound IGF. Cleavage of IGFBP-4 is dramatically enhanced by the presence of IGF, whereas cleavage of IGFBP-5 is slightly inhibited by the presence of IGF. |
| Protein Name | Pappalysin-1Insulin-Like Growth Factor-Dependent Igf-Binding Protein 4 ProteaseIgf-Dependent Igfbp-4 ProteaseIgfbp-4asePregnancy-Associated Plasma Protein APapp-A |
| Database Links | Reactome: R-HSA-381426 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pappalysin-1 antibodyAnti-Insulin-Like Growth Factor-Dependent Igf-Binding Protein 4 Protease antibodyAnti-Igf-Dependent Igfbp-4 Protease antibodyAnti-Igfbp-4ase antibodyAnti-Pregnancy-Associated Plasma Protein A antibodyAnti-Papp-A antibodyAnti-PAPPA antibody |
Information sourced from Uniprot.org