Anti-pan-FZD antibody [F6] {FITC} (STJA0028754)

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STJA0028754
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Host: Mouse
Applications: ELISA/FC/IF
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-pan-FZD is suitable for use in ELISA, Flow Cytometry and Immunofluorescence research applications.
Clonality : Monoclonal
Clone ID : F6
Conjugation: FITC
Isotype: IgG2ak
Formulation: 0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Purification: Purified
Concentration: 0.5 mg/mL
Storage Instruction: Store at 4°C for 12 months. Protect from light. Do not freeze.
Gene Symbol: FZD1
Gene ID: 8321
Uniprot ID: FZD1_HUMAN
Post Translational Modifications Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
Function Receptor for Wnt proteins. Activated by WNT3A, WNT3, WNT1 and to a lesser extent WNT2, but apparently not by WNT4, WNT5A, WNT5B, WNT6, WNT7A or WNT7B. Contradictory results showing activation by WNT7B have been described for mouse. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). (Microbial infection) Acts as a receptor for C.difficile toxin TcdB in the colonic epithelium.
Protein Name Frizzled-1
Fz-1
Hfz1
Fze1
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-373080
Reactome: R-HSA-4086400
Reactome: R-HSA-4608870
Reactome: R-HSA-4641262
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Frizzled-1 antibody
Anti-Fz-1 antibody
Anti-Hfz1 antibody
Anti-Fze1 antibody
Anti-FZD1 antibody

Information sourced from Uniprot.org