Anti-PAK5 antibody (600-700) (STJ118317)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PAK5 (600-700) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PAK5 |
| Gene ID | 57144 |
| Uniprot ID | PAK5_HUMAN |
| Immunogen Region | 600-700 |
| Immunogen Sequence | RKSLVGTPYWMAPEVISRLP YGTEVDIWSLGIMVIEMIDG EPPYFNEPPLQAMRRIRDSL PPRVKDLHKVSSVLRGFLDL MLVREPSQRATAQELLGHPF L |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 600-700 of human PAK5 (NP_065074.1). |
Additional Info
| Tissue Specificity | Predominantly expressed in brain. |
| Post Translational Modifications | Autophosphorylated when activated by CDC42/p21. |
| Function | Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions. |
| Protein Name | Serine/Threonine-Protein Kinase Pak 5P21-Activated Kinase 5Pak-5P21-Activated Kinase 7Pak-7 |
| Database Links | Reactome: R-HSA-428540Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013405Reactome: R-HSA-9013407 |
| Cellular Localisation | MitochondrionCytoplasmNucleusShuttles Between The Nucleus And The MitochondriaAnd Mitochondrial Localization Is Essential For The Role In Cell Survival |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Pak 5 antibodyAnti-P21-Activated Kinase 5 antibodyAnti-Pak-5 antibodyAnti-P21-Activated Kinase 7 antibodyAnti-Pak-7 antibodyAnti-PAK5 antibodyAnti-KIAA1264 antibodyAnti-PAK7 antibody |
Information sourced from Uniprot.org