| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PAG1 |
| Gene ID: |
55824 |
| Uniprot ID: |
PHAG1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of PAG1 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human PAG1 |
| Post Translational Modifications | Palmitoylated. Phosphorylated by FYN on Tyr-317 in resting T-cells.which promotes interaction with CSK. Dephosphorylated by PTPRC/CD45 upon TCR activation.which leads to CSK dissociation. May also be dephosphorylated by PTPN11. Hyperphosphorylated in mast cells upon FCER1 activation. Phosphorylated by LYN. |
| Function | Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. |
| Protein Name | Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1Csk-Binding ProteinTransmembrane Adapter Protein PagTransmembrane Phosphoprotein Cbp |
| Database Links | Reactome: R-HSA-180292Reactome: R-HSA-202427 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinPresent In Lipid Rafts |
| Alternative Antibody Names | Anti-Phosphoprotein Associated With Glycosphingolipid-Enriched Microdomains 1 antibodyAnti-Csk-Binding Protein antibodyAnti-Transmembrane Adapter Protein Pag antibodyAnti-Transmembrane Phosphoprotein Cbp antibodyAnti-PAG1 antibodyAnti-CBP antibodyAnti-PAG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
