| Short Description : | Rabbit polyclonal anti-Parkin coregulated gene protein (18-68 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PACRG |
| Gene ID: | 135138 |
| Uniprot ID: | PACRG_HUMAN |
| Immunogen: | Synthesized peptide derived from the human PACRG at the amino acid range 18-68 |
| Immunogen Region: | 18-68 aa |
| Specificity: | This antibody detects endogenous levels of PACRG at Human/Mouse |
| Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease. |
| Protein Name | Parkin Coregulated Gene ProteinMolecular Chaperone/Chaperonin-Binding ProteinPark2 Coregulated Gene Protein |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCilium AxonemeFlagellum Axoneme |
| Alternative Antibody Names | Anti-Parkin Coregulated Gene Protein antibodyAnti-Molecular Chaperone/Chaperonin-Binding Protein antibodyAnti-Park2 Coregulated Gene Protein antibodyAnti-PACRG antibodyAnti-GLUP antibody |
Information sourced from Uniprot.org
