| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
P2RX4 |
| Gene ID: |
5025 |
| Uniprot ID: |
P2RX4_HUMAN |
| Immunogen Region: |
55-338 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 55-338 of human P2RX4 (NP_110378.3). |
| Immunogen Sequence: |
QETDSVVSSVTTKVKGVAVT NTSKLGFRIWDVADYVIPAQ EENSLFVMTNVILTMNQTQG LCPEIPDATTVCKSDASCTA GSAGTHSNGVSTGRCVAFNG SVKTCEVAAWCPVEDDTHVP QPAFLKAAENFTLLVKNNIW YPKFNFSKRNILPNITTTYL KSCIYDAKTDPFCPIFRLGK IVENAGHSFQDMAVEGGIMG IQVNWDCNLDRAASLCLPRY SFRRLDTRDVEHNVSPGYN |
| Function | ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4. Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology. Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation. Participates also in basal T-cell activity without TCR/CD3 stimulation. Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC. Upon activation, drives microglia motility via the PI3K/Akt pathway. Could also function as an ATP-gated cation channel of lysosomal membranes. |
| Protein Name | P2x Purinoceptor 4P2x4Atp ReceptorPurinergic Receptor |
| Database Links | Reactome: R-HSA-139853Reactome: R-HSA-418346Reactome: R-HSA-9660826 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLysosome Membrane |
| Alternative Antibody Names | Anti-P2x Purinoceptor 4 antibodyAnti-P2x4 antibodyAnti-Atp Receptor antibodyAnti-Purinergic Receptor antibodyAnti-P2RX4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
