Anti-p16 INK4A antibody (1-100 aa) (STJ11105241)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal p16 INK4A (1-100 aa) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Cdkn2a |
| Gene ID | 12578 |
| Uniprot ID | CDN2A_MOUSE |
| Immunogen Region | 1-100 aa |
| Immunogen Sequence | MESAADRLARAAAQGRVHDV RALLEAGVSPNAPNSFGRTP IQVMMMGNVHVAALLLNYGA DSNCEDPTTFSRPVHDAARE GFLDTLVVLHGSGARLDVRD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of mouse p16 INK4A. (NP_001035744.1). |
Additional Info
| Post Translational Modifications | Phosphorylation seems to increase interaction with CDK4. |
| Function | Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein. |
| Protein Name | Cyclin-Dependent Kinase Inhibitor 2aCyclin-Dependent Kinase 4 Inhibitor ACdk4iP16-Ink4aP16-Ink4 |
| Database Links | |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase Inhibitor 2a antibodyAnti-Cyclin-Dependent Kinase 4 Inhibitor A antibodyAnti-Cdk4i antibodyAnti-P16-Ink4a antibodyAnti-P16-Ink4 antibodyAnti-Cdkn2a antibodyAnti-P16ink4a antibody |
Information sourced from Uniprot.org