Anti-p16 ARC antibody [R06-5H3] (STJA0035877)

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STJA0035877
£133.50 - £281.50
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Host: Rabbit
Applications: WB/IHC-P/ICC/IF/IP/FC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-p16 ARC for use in WB, IHC-P, ICC, IF, IP and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : R06-5H3
Conjugation: Unconjugated
Isotype: IgG
Formulation: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification: Affinity Chromatography
Dilution Range: WB 1:500-1:1000
IHC 1:50-1:100
IF 1:50-1:200
IP 1:50
FC 1:50-1:100
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: ARPC5
Gene ID: 10092
Uniprot ID: ARPC5_HUMAN
Immunogen: A synthesized peptide derived from human p16 ARC
Post Translational Modifications Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.
Function Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).
Protein Name Actin-Related Protein 2/3 Complex Subunit 5
Arp2/3 Complex 16 Kda Subunit
P16-Arc
Database Links Reactome: R-HSA-2029482
Reactome: R-HSA-3928662
Reactome: R-HSA-5663213
Reactome: R-HSA-6798695
Reactome: R-HSA-8856828
Reactome: R-HSA-9664422
Cellular Localisation Cytoplasm
Cytoskeleton
Cell Projection
Nucleus
Alternative Antibody Names Anti-Actin-Related Protein 2/3 Complex Subunit 5 antibody
Anti-Arp2/3 Complex 16 Kda Subunit antibody
Anti-P16-Arc antibody
Anti-ARPC5 antibody
Anti-ARC16 antibody

Information sourced from Uniprot.org

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