| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (105-155 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
OXCT1 |
| Gene ID: |
5019 |
| Uniprot ID: |
SCOT1_HUMAN |
| Immunogen Region: |
105-155 aa |
| Specificity: |
This antibody detects endogenous levels of SCOT1 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human SCOT1 at the amino acid range 105-155 |
| Function | Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production. Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. |
| Protein Name | Succinyl-Coa -3-Ketoacid Coenzyme A Transferase 1 - MitochondrialScot3-Oxoacid Coa-Transferase 1Somatic-Type Succinyl-Coa -3-Oxoacid Coa-TransferaseScot-SSuccinyl-Coa -3-Oxoacid Coa Transferase |
| Database Links | Reactome: R-HSA-77108 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Succinyl-Coa -3-Ketoacid Coenzyme A Transferase 1 - Mitochondrial antibodyAnti-Scot antibodyAnti-3-Oxoacid Coa-Transferase 1 antibodyAnti-Somatic-Type Succinyl-Coa -3-Oxoacid Coa-Transferase antibodyAnti-Scot-S antibodyAnti-Succinyl-Coa -3-Oxoacid Coa Transferase antibodyAnti-OXCT1 antibodyAnti-OXCT antibodyAnti-SCOT antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
