| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | O.sativa |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunogen Region: | 436-650 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 436-650 of Oryza sativa OsIRE1 (Q7XIT1). |
| Immunogen Sequence: | ARKKDGLINSTQIFSASDKE GNGTGGSTEAQSNKAHDSTN VELPNGLNGRQIGKLCVYSK EIGKGSNGTVVFEGSYGGRE VAVKRLLRSHNDIASKEIEN LIASDQDPNIVRMYGFEQDN DFVYISLERCRCSLADLIQL HSVPPFSNTKGTDIELWRQD GLPSAQLLKLMRDVVAGIVH LHSLGIIHRDLKPQNVLISK EGPLRAKLSDMGISK |
| Background | Involved in endoplasmic reticulum (ER) stress response. Senses unfolded proteins in the lumen of the ER via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices bZIP50 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response (UPR) transcriptional activator, which then induces transcription of UPR target genes, such as luminal-binding protein (BiP) chaperones. |
Information sourced from Uniprot.org
