| Post Translational Modifications | Phosphorylation is enhanced in vitro by phorbol-12-myristate-13-acetate (PMA), forskolin and calcium ionophore A23187. Phosphorylation seems to be stimulated in conditions of low cell-cell (or cell-matrix) adhesion. |
| Function | Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes. Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With VAPA, may regulate ER morphology. Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion. Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3. Also binds 25-hydroxycholesterol and cholesterol. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 3Orp-3Osbp-Related Protein 3 |
| Database Links | Reactome: R-HSA-192105 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinCytoplasmCytosolCell MembraneCell ProjectionFilopodium TipNucleus MembraneCo-Localizes With Osbpl6 At Contact Sites Between The Plasma Membrane And The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 3 antibodyAnti-Orp-3 antibodyAnti-Osbp-Related Protein 3 antibodyAnti-OSBPL3 antibodyAnti-KIAA0704 antibodyAnti-ORP3 antibodyAnti-OSBP3 antibody |
Information sourced from Uniprot.org
