Anti-OSBPL11 antibody (180-230 aa) (STJ194605)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human OSB11 at the amino acid range 180-230
General Information
| Short Description | Rabbit polyclonal anti-Oxysterol-binding protein-related protein 11 (180-230 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OSBPL11 |
| Gene ID | 114885 |
| Uniprot ID | OSB11_HUMAN |
| Immunogen | Synthesized peptide derived from the human OSB11 at the amino acid range 180-230 |
| Immunogen Region | 180-230 aa |
| Specificity | This antibody detects endogenous levels of OSB11 at Human/Mouse |
Additional Info
| Function | Plays a role in regulating ADIPOQ and FABP4 levels in differentiating adipocytes and is also involved in regulation of adipocyte triglyceride storage. Weakly binds 25-hydroxycholesterol. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex. |
| Protein Name | Oxysterol-Binding Protein-Related Protein 11Orp-11Osbp-Related Protein 11 |
| Database Links | Reactome: R-HSA-9013407 |
| Cellular Localisation | Late Endosome MembraneGolgi ApparatusTrans-Golgi Network MembraneLocalizes At The Golgi-Late Endosome Interface |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein-Related Protein 11 antibodyAnti-Orp-11 antibodyAnti-Osbp-Related Protein 11 antibodyAnti-OSBPL11 antibodyAnti-ORP11 antibodyAnti-OSBP12 antibody |
Information sourced from Uniprot.org