Anti-OSBP antibody (284-334 aa) (STJ194261)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human OSBP1 at the amino acid range 284-334
General Information
| Short Description | Rabbit polyclonal anti-Oxysterol-binding protein 1 (284-334 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OSBP |
| Gene ID | 5007 |
| Uniprot ID | OSBP1_HUMAN |
| Immunogen | Synthesized peptide derived from the human OSBP1 at the amino acid range 284-334 |
| Immunogen Region | 284-334 aa |
| Specificity | This antibody detects endogenous levels of OSBP1 at Human/Mouse |
Additional Info
| Function | Lipid transporter involved in lipid countertransport between the Golgi complex and membranes of the endoplasmic reticulum: specifically exchanges sterol with phosphatidylinositol 4-phosphate (PI4P), delivering sterol to the Golgi in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds cholesterol and a range of oxysterols including 25-hydroxycholesterol. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylates ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. |
| Protein Name | Oxysterol-Binding Protein 1 |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-192105 |
| Cellular Localisation | CytoplasmCytosolPerinuclear RegionGolgi Apparatus MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneGolgi ApparatusTrans-Golgi NetworkPredominantly Cytosolic |
| Alternative Antibody Names | Anti-Oxysterol-Binding Protein 1 antibodyAnti-OSBP antibodyAnti-OSBP1 antibody |
Information sourced from Uniprot.org