| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
HCRT |
| Gene ID: |
3060 |
| Uniprot ID: |
OREX_HUMAN |
| Immunogen Region: |
1-100 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Orexin B/Hypocretin-2. |
| Immunogen Sequence: |
MNLPSTKVSWAAVTLLLLLL LLPPALLSSGAAAQPLPDCC RQKTCSCRLYELLHGAGNHA AGILTLGKRRSGPPGLQGRL QRLLQASGNHAAGILTMGRR |
| Tissue Specificity | Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Specific enzymatic cleavages at paired basic residues yield the different active peptides. |
| Function | Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. Orexin-B: Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner. |
| Protein Name | Hypocretin Neuropeptide PrecursorHypocretinHcrtOrexin PrecursorPrepro-OrexinPreprohypocretin Cleaved Into - Orexin-AHypocretin-1Hcrt1 - Orexin-BHypocretin-2Hcrt2 |
| Database Links | Reactome: R-HSA-389397Reactome: R-HSA-416476 |
| Cellular Localisation | Rough Endoplasmic ReticulumCytoplasmic VesicleSynapseAssociated With Perikaryal Rough Endoplasmic Reticulum As Well As Cytoplasmic Large Granular Vesicles At Synapses |
| Alternative Antibody Names | Anti-Hypocretin Neuropeptide Precursor antibodyAnti-Hypocretin antibodyAnti-Hcrt antibodyAnti-Orexin Precursor antibodyAnti-Prepro-Orexin antibodyAnti-Preprohypocretin Cleaved Into - Orexin-A antibodyAnti-Hypocretin-1 antibodyAnti-Hcrt1 - Orexin-B antibodyAnti-Hypocretin-2 antibodyAnti-Hcrt2 antibodyAnti-HCRT antibodyAnti-OX antibodyAnti-PPORX antibodyAnti-PPOX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
