Anti-OR2AT4 antibody (271-320) (STJ94663)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human OR2AT4. AA range:271-320
General Information
| Short Description | Rabbit polyclonal anti-Olfactory receptor 2AT4 (271-320) for use in IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IF 1:200-1:1000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OR2AT4 |
| Gene ID | 341152 |
| Uniprot ID | O2AT4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human OR2AT4. AA range:271-320 |
| Immunogen Region | 271-320 |
| Specificity | Olfactory receptor 2AT4 Polyclonal Antibody detects endogenous levels of Olfactory receptor 2AT4 protein. |
Additional Info
| Tissue Specificity | Detected in the keratinocytes of the epidermis (at protein level). Detected in hair follicles in proximal outer root sheath and hair matrix keratinocytes (at protein level). |
| Function | Olfactory receptor. Activated by the synthetic sandalwood odorant sandalore. Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs. Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes. Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases. |
| Protein Name | Olfactory Receptor 2at4Olfactory Receptor Or11-265 |
| Database Links | Reactome: R-HSA-381753Reactome: R-HSA-9752946 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Olfactory Receptor 2at4 antibodyAnti-Olfactory Receptor Or11-265 antibodyAnti-OR2AT4 antibody |
Information sourced from Uniprot.org