Anti-Olig2 antibody (200-300aa) [ZR340] (STJ180473)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFragment (around aa 200-300) of human Olig2 protein
General Information
| Short Description | Rabbit monoclonal Olig2 (200-300aa) antibody for use in IHC-P in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ZR340 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purified |
| Dilution Range | 1:100-200 |
| Formulation | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Storage Instruction | Store at 2β8Β°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate labβstandardized diluent. Stability after dilution: 7 days at 24Β°C, 3 months at 2β8Β°C, 6months at β20Β°C. |
Target Information
| Gene Symbol | OLIG2 |
| Gene ID | 10215 |
| Uniprot ID | OLIG2_HUMAN |
| Immunogen | Fragment (around aa 200-300) of human Olig2 protein |
| Immunogen Region | 200-300aa |
| Specificity | Positive control: Astrocytoma |
Additional Info
| Tissue Specificity | Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable. |
| Function | Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Functions together with ZNF488 to promote oligodendrocyte differentiation. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development. |
| Protein Name | Oligodendrocyte Transcription Factor 2Oligo2Class B Basic Helix-Loop-Helix Protein 1Bhlhb1Class E Basic Helix-Loop-Helix Protein 19Bhlhe19Protein Kinase C-Binding Protein 2Protein Kinase C-Binding Protein Rack17 |
| Database Links | |
| Cellular Localisation | NucleusCytoplasmThe Nls Contained In The Bhlh Domain Could Be Masked In The Native Form And Translocation To The Nucleus Could Be Mediated By Interaction Either With Class E Bhlh Partner Protein Or With Nkx2-2 |
| Alternative Antibody Names | Anti-Oligodendrocyte Transcription Factor 2 antibodyAnti-Oligo2 antibodyAnti-Class B Basic Helix-Loop-Helix Protein 1 antibodyAnti-Bhlhb1 antibodyAnti-Class E Basic Helix-Loop-Helix Protein 19 antibodyAnti-Bhlhe19 antibodyAnti-Protein Kinase C-Binding Protein 2 antibodyAnti-Protein Kinase C-Binding Protein Rack17 antibodyAnti-OLIG2 antibodyAnti-BHLHB1 antibodyAnti-BHLHE19 antibodyAnti-PRKCBP2 antibodyAnti-RACK17 antibody |
Information sourced from Uniprot.org