Anti-OLFM4 antibody (211-510) (STJ117582)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal OLFM4 (211-510) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OLFM4 |
| Gene ID | 10562 |
| Uniprot ID | OLFM4_HUMAN |
| Immunogen Region | 211-510 |
| Immunogen Sequence | AIRREIVALKTKLKECEASK DQNTPVVHPPPTPGSCGHGG VVNISKPSVVQLNWRGFSYL YGAWGRDYSPQHPNKGLYWV APLNTDGRLLEYYRLYNTLD DLLLYINARELRITYGQGSG TAVYNNNMYVNMYNTGNIAR VNLTTNTIAVTQTLPNAAYN NRFSYANVAWQDIDFAVDEN GLWVIYSTEASTGNMVISKL NDTTLQVLNTWYTKQYKPSA SNAFMVCGVLYATRTMNTR |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 211-510 of human OLFM4 (NP_006409.3). |
Additional Info
| Tissue Specificity | Expressed during myeloid lineage development. Much higher expression in bone marrow neutrophils than in peripheral blood neutrophils (at protein level). Strongly expressed in the prostate, small intestine and colon and moderately expressed in the bone marrow and stomach. Overexpressed in some pancreatic cancer tissues. |
| Post Translational Modifications | N-glycosylated. |
| Function | May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. |
| Protein Name | Olfactomedin-4Olm4Antiapoptotic Protein Gw112G-Csf-Stimulated Clone 1 ProteinHgc-1Holfd |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceMitochondrionSubcellular Location Is Not Clearly Defined: Has Been Shown To Be SecretedBut Also In The MitochondrionCytoplasm And Plasma Membrane And In The Nucleus |
| Alternative Antibody Names | Anti-Olfactomedin-4 antibodyAnti-Olm4 antibodyAnti-Antiapoptotic Protein Gw112 antibodyAnti-G-Csf-Stimulated Clone 1 Protein antibodyAnti-Hgc-1 antibodyAnti-Holfd antibodyAnti-OLFM4 antibodyAnti-GW112 antibodyAnti-UNQ362 antibodyAnti-PRO698 antibody |
Information sourced from Uniprot.org