| Host: | Mouse | 
| Applications: | IHC-P | 
| Reactivity: | Human | 
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. | 
| Short Description : | Mouse monoclonal antibody anti-OCT2 is suitable for use in Immunohistochemistry research applications. | 
| Clonality : | Monoclonal | 
| Clone ID : | MRQ-2 | 
| Conjugation: | Unconjugated | 
| Isotype: | IgG1 | 
| Formulation: | Tris Buffer, pH 7.3-7.7, containing 1% BSA and <0.1% Sodium Azide | 
| Dilution Range: | IHC 1:25 – 1:100 | 
| Storage Instruction: | Store at 2-8°C upon receipt. | 
| Background | Oct-2 is a transcription factor of the POU homeo-domain family that binds to the Ig gene octamer sites, regulating B-cell-specific genes. These are involved in proliferation and differentiation and, despite the scarce evidence for Oct-2 expression in T cells, it has been shown that this factor participates in transcriptional regulation during T-cell activation. Oct-2 activity is dependent on phosphorylation and alternatitive splicing.Various lymphomas are also positive for this marker including the following: Bchronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, marginal zone lymphoma, plasmacytoma, Burkitt lymphoma, diffuse large cell lymphoma, diffuse large B-cell lymphoma, T-cell rich B-cell lymphoma, nodular lymphocyte predominant Hodgkin lymphoma, and classic Hodgkin lymphoma. | 
Information sourced from Uniprot.org
 
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