Anti-OAS3 antibody (320-620) (STJ113646)

Name: Anti-OAS3 antibody (320-620) (STJ113646)
SKU: STJ113646
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ113646

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Short Description	Rabbit polyclonal OAS3 (320-620) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/IF/ICC/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:100-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	OAS3
Gene ID	4940
Uniprot ID	OAS3_HUMAN
Immunogen Region	320-620
Immunogen Sequence	AASCYDHPCFLRGMGDPVQS WKGPGLPRAGCSGLGHPIQL DPNQKTPENSKSLNAVYPRA GSKPPSCPAPGPTGAASIVP SVPGMALDLSQIPTKELDRF IQDHLKPSPQFQEQVKKAID IILRCLHENCVHKASRVSKG GSFGRGTDLRDGCDVELIIF LNCFTDYKDQGPRRAEILDE MRAQLESWWQDQVPSLSLQF PEQNVPEALQFQLVSTALKS WTDVSLLPAFDAVGQLSSG
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 320-620 of human OAS3 (NP_006178.2).

Tissue Specificity	Present at high level in placenta trophoblast.
Function	Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Protein Name	2'-5'-Oligoadenylate Synthase 3 (2-5'Oligo(A Synthase 3 2-5a Synthase 3 P100 Oas P100oas
Database Links	Reactome: R-HSA-877300 Reactome: R-HSA-8983711 Reactome: R-HSA-909733
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-2'-5'-Oligoadenylate Synthase 3 antibody Anti-(2-5'Oligo(A Synthase 3 antibody Anti-2-5a Synthase 3 antibody Anti-P100 Oas antibody Anti-P100oas antibody Anti-OAS3 antibody Anti-P antibody Anti-OKcl.4 antibody

Information sourced from Uniprot.org