| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-NUP98 (621-920) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:1000-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUP98 |
| Gene ID: | 4928 |
| Uniprot ID: | NUP98_HUMAN |
| Immunogen Region: | 621-920 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 621-920 of human NUP98 (NP_624357.1). |
| Immunogen Sequence: | SKPVDENHQQDGDEDSLVSH FYTNPIAKPIPQTPESAGNK HSNSNSVDDTIVALNMRAAL RNGLEGSSEETSFHDESLQD DREEIENNSYHMHPAGIILT KVGYYTIPSMDDLAKITNEK GECIVSDFTIGRKGYGSIYF EGDVNLTNLNLDDIVHIRRK EVVVYLDDNQKPPVGEGLNR KAEVTLDGVWPTDKTSRCLI KSPDRLADINYEGRLEAVSR KQGAQFKEYRPETGSWVFK |
| Post Translational Modifications | Isoform 1 to isoform 4 are autoproteolytically cleaved to yield Nup98 and Nup96 or Nup98 only, respectively. Cleaved Nup98 is necessary for the targeting of Nup98 to the nuclear pore and the interaction with Nup96. Proteolytically degraded after poliovirus (PV) infection.degradation is partial and NCP- and TPR-binding domains withstand degradation. |
| Function | Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. NUP98 and NUP96 are involved in the bidirectional transport across the NPC. May anchor NUP153 and TPR to the NPC. In cooperation with DHX9, plays a role in transcription and alternative splicing activation of a subset of genes. Involved in the localization of DHX9 in discrete intranuclear foci (GLFG-body). (Microbial infection) Interacts with HIV-1 capsid protein P24 and nucleocapsid protein P7 and may thereby promote the integration of the virus in the host nucleus (in vitro). Binding affinity to HIV-1 CA-NC complexes bearing the capsid change Asn-74-Asp is reduced (in vitro). |
| Protein Name | Nuclear Pore Complex Protein Nup98-Nup96 Cleaved Into - Nuclear Pore Complex Protein Nup9898 Kda NucleoporinNucleoporin Nup98Nup98 - Nuclear Pore Complex Protein Nup9696 Kda NucleoporinNucleoporin Nup96Nup96 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-141444 P52948-5Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-2467813 P52948-5Reactome: R-HSA-2500257 P52948-5Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-5663220 P52948-5Reactome: R-HSA-6784531Reactome: R-HSA-68877 P52948-5Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9615933 P52948-5Reactome: R-HSA-9648025 P52948-5Reactome: R-HSA-9705671 |
| Cellular Localisation | Nucleus MembranePeripheral Membrane ProteinNucleoplasmic SideNucleusNuclear Pore ComplexNucleoplasmLocalized To The Nucleoplasmic Side Of The Nuclear Pore Complex (Npc)At Or Near The Nucleoplasmic BasketDissociates From The Dissasembled Npc Structure Early During Prophase Of MitosisColocalized With Nup153 And Tpr To The Nuclear Basket Of NpcColocalized With Dhx9 In Diffuse And Discrete Intranuclear Foci (Glfg-Body)(Microbial Infection) Remains Localized To The Nuclear Membrane After Poliovirus (Pv) Infection |
| Alternative Antibody Names | Anti-Nuclear Pore Complex Protein Nup98-Nup96 Cleaved Into - Nuclear Pore Complex Protein Nup98 antibodyAnti-98 Kda Nucleoporin antibodyAnti-Nucleoporin Nup98 antibodyAnti-Nup98 - Nuclear Pore Complex Protein Nup96 antibodyAnti-96 Kda Nucleoporin antibodyAnti-Nucleoporin Nup96 antibodyAnti-Nup96 antibodyAnti-NUP98 antibodyAnti-ADAR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
