| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit monoclonal antibody anti-Nuclear Pore Complex Protein Nup155 (901-1050) is suitable for use in Western Blot research applications. |
| Clonality: | Monoclonal |
| Clone ID: | S4195RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUP155 |
| Gene ID: | 9631 |
| Uniprot ID: | NU155_HUMAN |
| Immunogen Region: | 901-1050 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 901-1050 of human NUP155 (NP_705618.1). |
| Immunogen Sequence: | LKEYQKISNQVDLSNVCAQY RQVRFYEGVVELSLTAAEKK DPQGLGLHFYKHGEPEEDIV GLQAFQERLNSYKCITDTLQ ELVNQSKAAPQSPSVPKKPG PPVLSSDPNMLSNEEAGHHF EQMLKLSQRSKDELFSIALY NWLIQVDLAD |
| Tissue Specificity | Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis. Disulfide-linked to NUP62. The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC. |
| Function | Essential component of nuclear pore complex. Could be essessential for embryogenesis. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport. |
| Protein Name | Nuclear Pore Complex Protein Nup155155 Kda NucleoporinNucleoporin Nup155 |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-159227Reactome: R-HSA-159230Reactome: R-HSA-159231Reactome: R-HSA-159236Reactome: R-HSA-165054Reactome: R-HSA-168271Reactome: R-HSA-168276Reactome: R-HSA-168325Reactome: R-HSA-168333Reactome: R-HSA-170822Reactome: R-HSA-180746Reactome: R-HSA-180910Reactome: R-HSA-191859Reactome: R-HSA-3108214Reactome: R-HSA-3232142Reactome: R-HSA-3301854Reactome: R-HSA-3371453Reactome: R-HSA-4085377Reactome: R-HSA-4551638Reactome: R-HSA-4570464Reactome: R-HSA-4615885Reactome: R-HSA-5578749Reactome: R-HSA-5619107Reactome: R-HSA-6784531Reactome: R-HSA-9609690Reactome: R-HSA-9610379Reactome: R-HSA-9615933Reactome: R-HSA-9705671 |
| Cellular Localisation | NucleusNuclear Pore ComplexNucleus MembranePeripheral Membrane ProteinCytoplasmic SideNucleoplasmic SideIn MitosisAssumes A Diffuse Cytoplasmic Distribution Probably As A MonomerBefore Reversing Back Into A Punctate Nuclear Surface Localization At The End Of Mitosis |
| Alternative Antibody Names | Anti-Nuclear Pore Complex Protein Nup155 antibodyAnti-155 Kda Nucleoporin antibodyAnti-Nucleoporin Nup155 antibodyAnti-NUP155 antibodyAnti-KIAA0791 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
