| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S8MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NUP153 |
| Gene ID: | 9972 |
| Uniprot ID: | NU153_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NUP153 (P49790). |
| Immunogen Sequence: | MASGAGGVGGGGGGKIRTRR CHQGPIKPYQQGRQQHQGIL SRVTESVKNIVPGWLQRYFN KNEDVCSCSTDTSEVPRWPE NKEDHLVYADEESSNITDGR |
| Post Translational Modifications | Phosphorylated in interphase, hyperphosphorylated during mitosis. May play a role in the reversible disassembly of the nuclear pore complex during mitosis. Proteolytically degraded after poliovirus (PV) infection.degradation is partial and NCP- and TPR-binding domains withstand degradation. O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status. |
| Function | Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus.in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC). (Microbial infection) Interacts with HIV-1 caspid protein P24 and thereby promotes the integration of the virus in the nucleus of non-dividing cells (in vitro). (Microbial infection) Binds HIV-2 protein vpx and thereby promotes the nuclear translocation of the lentiviral genome (in vitro). |
| Protein Name | Nuclear Pore Complex Protein Nup153 153 Kda Nucleoporin Nucleoporin Nup153 |
| Database Links | Reactome: R-HSA-1169408 Reactome: R-HSA-159227 Reactome: R-HSA-159230 Reactome: R-HSA-159231 Reactome: R-HSA-159236 Reactome: R-HSA-165054 Reactome: R-HSA-168271 Reactome: R-HSA-168276 Reactome: R-HSA-168325 Reactome: R-HSA-168333 Reactome: R-HSA-170822 Reactome: R-HSA-180746 Reactome: R-HSA-180910 Reactome: R-HSA-191859 Reactome: R-HSA-3108214 Reactome: R-HSA-3232142 Reactome: R-HSA-3301854 Reactome: R-HSA-3371453 Reactome: R-HSA-4085377 Reactome: R-HSA-4551638 Reactome: R-HSA-4570464 Reactome: R-HSA-4615885 Reactome: R-HSA-5578749 Reactome: R-HSA-5619107 Reactome: R-HSA-6784531 Reactome: R-HSA-9609690 Reactome: R-HSA-9610379 Reactome: R-HSA-9705671 |
| Cellular Localisation | Nucleus Nucleus Membrane Nuclear Pore Complex Tightly Associated With The Nuclear Membrane And Lamina Localized To The Nucleoplasmic Side Of The Nuclear Pore Complex (Npc) Core Structure Forming A Fibrous Structure Called The Nuclear Basket Dissociates From The Npc Structure Early During Prophase Of Mitosis Integrated In The Newly Assembled Nuclear Envelope Of Postmitotic Cells Early In G1 Colocalized With Nup98 And Tpr To The Nuclear Basket At The Nucleoplasmic Side Of The Npc Detected In Diffuse And Discrete Intranuclear Foci Remained Localized To The Nuclear Membrane After Poliovirus (Pv) Infection |
| Alternative Antibody Names | Anti-Nuclear Pore Complex Protein Nup153 antibody Anti-153 Kda Nucleoporin antibody Anti-Nucleoporin Nup153 antibody Anti-NUP153 antibody |
Information sourced from Uniprot.org