| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-NUMBL (330-609) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NUMBL |
| Gene ID: |
9253 |
| Uniprot ID: |
NUMBL_HUMAN |
| Immunogen Region: |
330-609 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 330-609 of human NUMBL (NP_004747.1). |
| Immunogen Sequence: |
LPSTLQRRTDFQVKGTVPEM EPPGAGDSDSINALCTQISS SFASAGAPAPGPPPATTGTS AWGEPSVPPAAAFQPGHKRT PSEAERWLEEVSQVAKAQQQ QQQQQQQQQQQQQQQQQAAS VAPVPTMPPALQPFPAPVGP FDAAPAQVAVFLPPPHMQPP FVPAYPGLGYPPMPRVPVVG ITPSQMVANAFCSAAQLQPQ PATLLGKAGAFPPPAIPSAP GSQARPRPNGAPWPPEPAP |
| Function | Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons. |
| Protein Name | Numb-Like ProteinNumb-Related ProteinNumb-R |
| Cellular Localisation | CytoplasmSymmetrically Distributed Throughout The Cytoplasm In Non Dividing Neuroblasts Of The Cns |
| Alternative Antibody Names | Anti-Numb-Like Protein antibodyAnti-Numb-Related Protein antibodyAnti-Numb-R antibodyAnti-NUMBL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
