| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
NUF2 |
| Gene ID: |
83540 |
| Uniprot ID: |
NUF2_HUMAN |
| Immunogen Region: |
165-464 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 165-464 of human NUF2 (NP_663735.2). |
| Immunogen Sequence: |
KLERLDSVPVEEQEEFKQLS DGIQELQQSLNQDFHQKTIV LQEGNSQKKSNISEKTKRLN ELKLSVVSLKEIQESLKTKI VDSPEKLKNYKEKMKDTVQK LKNARQEVVEKYEIYGDSVD CLPSCQLEVQLYQKKIQDLS DNREKLASILKESLNLEDQI ESDESELKKLKTEENSFKRL MIVKKEKLATAQFKINKKHE DVKQYKRTVIEDCNKVQEKR GAVYERVTTINQEIQKIKL |
| Post Translational Modifications | Can be phosphorylated by AURKA and AURKB. |
| Function | Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. |
| Protein Name | Kinetochore Protein Nuf2Hnuf2Hnuf2rHsnuf2Cell Division Cycle-Associated Protein 1 |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-5663220Reactome: R-HSA-68877Reactome: R-HSA-9648025 |
| Cellular Localisation | NucleusChromosomeCentromereKinetochoreLocalizes To Kinetochores From Late Prophase To AnaphaseLocalizes Specifically To The Outer Plate Of The KinetochoreNdc80 Is Required For Efficient Kinetochore Localization |
| Alternative Antibody Names | Anti-Kinetochore Protein Nuf2 antibodyAnti-Hnuf2 antibodyAnti-Hnuf2r antibodyAnti-Hsnuf2 antibodyAnti-Cell Division Cycle-Associated Protein 1 antibodyAnti-NUF2 antibodyAnti-CDCA1 antibodyAnti-NUF2R antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
