Anti-NTSR1 antibody (1-70) (STJ11100896)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal NTSR1 (1-70) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NTSR1 |
| Gene ID | 4923 |
| Uniprot ID | NTR1_HUMAN |
| Immunogen Region | 1-70 |
| Immunogen Sequence | MRLNSSAPGTPGTPAADPFQ RAQAGLEEALLAPGFGNASG NASERVLAAPSSELDVNTDI YSKVLVTAVY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-70 of human NTSR1 (NP_002522.2). |
Additional Info
| Tissue Specificity | Expressed in prostate (at protein level). Detected in colon and peripheral blood mononuclear cells. Detected at very low levels in brain. |
| Post Translational Modifications | N-glycosylated. Palmitoylated.this is required for normal localization at membrane rafts and normal GNA11-mediated activation of down-stream signaling cascades. The palmitoylation level increases in response to neurotensin treatment. |
| Function | G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis. |
| Protein Name | Neurotensin Receptor Type 1Nt-R-1Ntr1High-Affinity Levocabastine-Insensitive Neurotensin ReceptorNtrh |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinMembrane RaftPalmitoylation Is Required For Localization At Cav1-Enriched Membrane Rafts |
| Alternative Antibody Names | Anti-Neurotensin Receptor Type 1 antibodyAnti-Nt-R-1 antibodyAnti-Ntr1 antibodyAnti-High-Affinity Levocabastine-Insensitive Neurotensin Receptor antibodyAnti-Ntrh antibodyAnti-NTSR1 antibodyAnti-NTRR antibody |
Information sourced from Uniprot.org