| Host: | Mouse |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-NT-3 growth factor receptor (32-429 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 4G5 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NTRK3 |
| Gene ID: | 4916 |
| Uniprot ID: | NTRK3_HUMAN |
| Immunogen Region: | 32-429 aa |
| Specificity: | Trk C Monoclonal Antibody detects endogenous levels of Trk C protein. |
| Immunogen: | Purified recombinant extracellular fragment of human Trk C (aa32-429) fused with hIgGFc tag expressed in HEK293 cells. |
| Post Translational Modifications | Ligand-mediated auto-phosphorylation. |
| Function | Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. |
| Protein Name | Nt-3 Growth Factor ReceptorGp145-TrkcTrk-CNeurotrophic Tyrosine Kinase Receptor Type 3Trkc Tyrosine Kinase |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-388844Reactome: R-HSA-6811558Reactome: R-HSA-9034013Reactome: R-HSA-9034015Reactome: R-HSA-9034793Reactome: R-HSA-9034864Reactome: R-HSA-9603381Reactome: R-HSA-9603505 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Nt-3 Growth Factor Receptor antibodyAnti-Gp145-Trkc antibodyAnti-Trk-C antibodyAnti-Neurotrophic Tyrosine Kinase Receptor Type 3 antibodyAnti-Trkc Tyrosine Kinase antibodyAnti-NTRK3 antibodyAnti-TRKC antibody |
Information sourced from Uniprot.org
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