![Anti-NTAL antibody [NAP-07] (STJ16100207)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/148925/346547/STJ16100207_1__49315.1681998607.jpg?c=1 "Anti-NTAL antibody [NAP-07] (STJ16100207)")
![Anti-NTAL antibody [NAP-07] (STJ16100207)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/148925/346547/STJ16100207_1__49315.1681998607.jpg?c=1 "Anti-NTAL antibody [NAP-07] (STJ16100207)")
Anti-NTAL antibody [NAP-07] (STJ16100207)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenRecombinant cytoplasmic domain (aa 91-243) of human NTAL.
General Information
| Short Description | Mouse monoclonal anti-NTAL for use in FC, IP, WB and ICC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/IP/WB/ICC |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | NAP-07 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Formulation | Phosphate buffered saline (PBS) solution with 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | LAT2 |
| Gene ID | 7462 |
| Uniprot ID | NTAL_HUMAN |
| Immunogen | Recombinant cytoplasmic domain (aa 91-243) of human NTAL. |
Additional Info
| Tissue Specificity | Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells.which induces the recruitment of GRB2. May be polyubiquitinated. |
| Function | Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. |
| Protein Name | Linker For Activation Of T-Cells Family Member 2Linker For Activation Of B-CellsMembrane-Associated Adapter MoleculeNon-T-Cell Activation LinkerWilliams-Beuren Syndrome Chromosomal Region 15 ProteinWilliams-Beuren Syndrome Chromosomal Region 5 Protein |
| Database Links | Reactome: R-HSA-2730905 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinPresent In Lipid Rafts |
| Alternative Antibody Names | Anti-Linker For Activation Of T-Cells Family Member 2 antibodyAnti-Linker For Activation Of B-Cells antibodyAnti-Membrane-Associated Adapter Molecule antibodyAnti-Non-T-Cell Activation Linker antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 15 Protein antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 5 Protein antibodyAnti-LAT2 antibodyAnti-LAB antibodyAnti-NTAL antibodyAnti-WBS15 antibodyAnti-WBSCR15 antibodyAnti-WBSCR5 antibodyAnti-HSPC046 antibody |
Information sourced from Uniprot.org