Anti-NSFL1C antibody (STJA0007189)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human NSFL1C
General Information
| Short Description | Rabbit polyclonal anti-NSFL1 cofactor p47 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NSFL1C |
| Gene ID | 55968 |
| Uniprot ID | NSF1C_HUMAN |
| Immunogen | Synthesized peptide derived from human NSFL1C |
| Specificity | This antibody detects endogenous levels of NSFL1C at Human, Mouse, Rat |
Additional Info
| Function | Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis. |
| Protein Name | Nsfl1 Cofactor P47Ubx Domain-Containing Protein 2cP97 Cofactor P47 |
| Database Links | Reactome: R-HSA-9013407 |
| Cellular Localisation | NucleusGolgi ApparatusGolgi StackChromosomeCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomePredominantly Nuclear In Interphase CellsBound To The Axial Elements Of Sex Chromosomes In Pachytene SpermatocytesA Small Proportion Of The Protein Is CytoplasmicAssociated With Golgi StacksLocalizes To Centrosome During Mitotic Prophase And Metaphase |
| Alternative Antibody Names | Anti-Nsfl1 Cofactor P47 antibodyAnti-Ubx Domain-Containing Protein 2c antibodyAnti-P97 Cofactor P47 antibodyAnti-NSFL1C antibodyAnti-UBXN2C antibody |
Information sourced from Uniprot.org