Anti-NRCAM antibody (1050-1130 aa) (STJ192457)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 1050-1130
General Information
| Short Description | Rabbit polyclonal anti-Neuronal cell adhesion molecule (1050-1130 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NRCAM |
| Gene ID | 4897 |
| Uniprot ID | NRCAM_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 1050-1130 |
| Immunogen Region | 1050-1130 aa |
| Specificity | NRCAM Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Cell adhesion protein that is required for normal responses to cell-cell contacts in brain and in the peripheral nervous system. Plays a role in neurite outgrowth in response to contactin binding. Plays a role in mediating cell-cell contacts between Schwann cells and axons. Plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes.not required for the formation of mature nodes with normal sodium channel clusters. Required, together with GLDN, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. |
| Protein Name | Neuronal Cell Adhesion MoleculeNr-CamNeuronal Surface Protein BravoHbravoNgcam-Related Cell Adhesion MoleculeNg-Cam-Related |
| Database Links | Reactome: R-HSA-445095Reactome: R-HSA-447038Reactome: R-HSA-447043 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionAxonSecretedDetected At Nodes Of Ranvier |
| Alternative Antibody Names | Anti-Neuronal Cell Adhesion Molecule antibodyAnti-Nr-Cam antibodyAnti-Neuronal Surface Protein Bravo antibodyAnti-Hbravo antibodyAnti-Ngcam-Related Cell Adhesion Molecule antibodyAnti-Ng-Cam-Related antibodyAnti-NRCAM antibodyAnti-KIAA0343 antibody |
Information sourced from Uniprot.org