| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-NRADD (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | Nradd |
| Gene ID: | 67169 |
| Uniprot ID: | NRADD_MOUSE |
| Immunogen Region: | N-Term |
| Specificity: | Specific for NRADD. |
| Immunogen: | A synthetic peptide from n-terminal region of mouse Neurotrophin receptor associated death domain (NRADD) conjugated to blue carrier protein was used as the antigen. |
| Function | Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR. |
| Protein Name | Death Domain-Containing Membrane Protein NraddNeurotrophin Receptor Homolog-2Nrh2Neurotrophin Receptor-Alike Death Domain Protein |
| Cellular Localisation | Cell MembraneSingle-Pass Type Iii Membrane ProteinNucleusProteolytic Processing Gives Rise To An Intracellular Domain That Translocates To The Nucleus |
| Alternative Antibody Names | Anti-Death Domain-Containing Membrane Protein Nradd antibodyAnti-Neurotrophin Receptor Homolog-2 antibodyAnti-Nrh2 antibodyAnti-Neurotrophin Receptor-Alike Death Domain Protein antibodyAnti-Nradd antibody |
Information sourced from Uniprot.org