| Short Description : | Rabbit polyclonal Nuclear Receptor Subfamily 4 Group A Member 2 (90-170) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NR4A2 |
| Gene ID: | 4929 |
| Uniprot ID: | NR4A2_HUMAN |
| Immunogen Region: | 90-170 |
| Immunogen Sequence: | IKVEDIQMHNYQQHSHLPPQ SEEMMPHSGSVYYKPSSPPT PTTPGFQVQHSPMWDDPGSL HNFHQNYVATTHMIEQRKTP V |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 90-170 of human NR4A2 (NP_006177.1). |
| Tissue Specificity | Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in brain tissue. |
| Function | Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. |
| Protein Name | Nuclear Receptor Subfamily 4 Group A Member 2Immediate-Early Response Protein NotOrphan Nuclear Receptor Nurr1Transcriptionally-Inducible Nuclear Receptor |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | CytoplasmNucleusMostly NuclearOxidative Stress Promotes Cytoplasmic Localization |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 4 Group A Member 2 antibodyAnti-Immediate-Early Response Protein Not antibodyAnti-Orphan Nuclear Receptor Nurr1 antibodyAnti-Transcriptionally-Inducible Nuclear Receptor antibodyAnti-NR4A2 antibodyAnti-NOT antibodyAnti-NURR1 antibodyAnti-TINUR antibody |
Information sourced from Uniprot.org
