| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Nuclear receptor subfamily 1 group I member 2 (91-140 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NR1I2 |
| Gene ID: |
8856 |
| Uniprot ID: |
NR1I2_HUMAN |
| Immunogen Region: |
91-140 aa |
| Specificity: |
PXR Polyclonal Antibody detects endogenous levels of PXR protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human NR1I2 at the amino acid range 91-140 |
| Function | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 2Orphan Nuclear Receptor Par1Orphan Nuclear Receptor PxrPregnane X ReceptorSteroid And Xenobiotic ReceptorSxr |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 O75469-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 1 Group I Member 2 antibodyAnti-Orphan Nuclear Receptor Par1 antibodyAnti-Orphan Nuclear Receptor Pxr antibodyAnti-Pregnane X Receptor antibodyAnti-Steroid And Xenobiotic Receptor antibodyAnti-Sxr antibodyAnti-NR1I2 antibodyAnti-PXR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
