| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | NPTN |
| Gene ID: | 27020 |
| Uniprot ID: | NPTN_HUMAN |
| Immunogen Region: | 29-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-200 of human NPTN (NP_059429.1). |
| Immunogen Sequence: | QNEPRIVTSEEVIIRDSPVL PVTLQCNLTSSSHTLTYSYW TKNGVELSATRKNASNMEYR INKPRAEDSGEYHCVYHFVS APKANATIEVKAAPDITGHK RSENKNEGQDATMYCKSVGY PHPDWIWRKKENGMPMDIVN TSGRFFIINKENYTELNIVN LQITEDPGEYEC |
| Tissue Specificity | Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level). |
| Function | Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. Also acts as a chaperone for ATP2B1.stabilizes ATP2B1 and increases its ATPase activity. Promotes localization of XKR8 at the cell membrane. |
| Protein Name | NeuroplastinStromal Cell-Derived Receptor 1Sdr-1 |
| Database Links | Reactome: R-HSA-977443 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Postsynaptic Density |
| Alternative Antibody Names | Anti-Neuroplastin antibodyAnti-Stromal Cell-Derived Receptor 1 antibodyAnti-Sdr-1 antibodyAnti-NPTN antibodyAnti-SDFR1 antibodyAnti-SDR1 antibody |
Information sourced from Uniprot.org